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All About Acne

Acne (Acne vulgaris) is a chronic skin condition characterized by pimples, comedones (blackheads/whiteheads), cysts, or nodules.

Codex Labs provides supplements & topicals for long-term acne clearance.

What causes acne?

OILY SKIN (HYPERSEBORRHEA)

OILY SKIN (HYPERSEBORRHEA) Overlay
Skin’s natural oil (sebum) can accumulate in and eventually clog pores, thereby creating a breeding ground for acne-causing bacteria which can trigger pimples, pustules, and cysts.

DEAD SKIN CELLS (HYPERKERATINIZATION)

DEAD SKIN CELLS (HYPERKERATINIZATION) Overlay
Pores become clogged due to a decrease in desquamation (shedding of dead skin cells), coupled with an increase in their cohesion (stickiness).

HORMONAL IMBALANCE

HORMONAL IMBALANCE Overlay
Increased levels of male sex hormones (androgens) cause sebaceous glands in the skin to overproduce sebum (oil), leading to excessively oily skin and clogged pores.

INFLAMMATION

INFLAMMATION Overlay
Pores clogged with dead skin cells and acne-causing bacteria trigger an immune response, causing redness and swelling in pimples and cysts which can lead to scarring.

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Types of acne

Acne can occur on your face or body.  There are five different types of acne.  

Comedonal

Hair follicles plugged with sebum (blackheads, whiteheads)

Inflammatory

Small, raised, inflamed pink or red bumps (papules) that can have a pus-filled tip (pustules)

Cystic

Severe form with deep, painful, pus-filled inflammatory cysts

Nodular

Severe form with large, painful, solid lesions deep within the skin (nodules)

Fungal

Itchy, red bumps caused by overgrowth of yeast in hair follices

ACNE SEVERITY (GRADE)

Acne type and symptoms can vary in severity and skin color.  While acne may be often hormonal in origin (puberty, menstrual cycle, PCOS), it also can be triggered by internal inflammation, environmental factors (pollution, rubbing), diet, and genetics.  

Acne severity is typically classified as mild, moderate, or severe based on the number and type of lesions, with a 4-grade system.

If you suspect that you or your teen has acne, the first step is to consult with a physician.

Mild (grade 1)

Characterized by open and closed comedones (whiteheads and blackheads) with few inflammatory papules and pustules

Moderate (grade 2)

Involves more papules and pustules, primarily on the face

Moderatately severe (grade 3)

Features numerous papules and pustules, along with occasional inflamed nodules, and can affect the chest and back

severe (grade 4)

Marked by many large, painful nodules and pustules

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Acne needs
a holistic approach

Acne (acne vulgaris) is a complex skin condition that can be influenced by many different factors.  These include genetics, diet, stress, certain environmental triggers, and especially, gut health.

Acne can vary in severity and may lead to scarring if not treated properly. Therefore, addressing only topical symptoms is usually not enough to successfully manage existing, and/or help to avoid future, breakouts.

Our comprehensive skin-gut-brain-biome approach has been intentionally designed to identify and manage all underlying contributors to achieve long-term clearance.  Join us in helping to solve acne by addressing both the inside and outside of the body.

Stories of Skin Transformation

Dermbunny
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Dermbunny

Erik Shoji
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Erik Shoji

Skincareanarchy
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Skincareanarchy

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Real Codex Users

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“Codex Labs is a unique blend of science and innovation that really works! It's my new go-to skincare line, both personally and for my acne patients.”

- Dr. Aarti Patel, N.D.

watch our founders TEDX TALK

What if the key to healing your skin wasn’t a cream, but a deeper understanding of your gut, your brain, and your invisible microbiome? Barbara explores the idea that compromised skin must be treated through the gut barrier and microbiome, and that your mental health may significantly affect your skin condition.

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Learn More About
Solving Acne From The Inside-Out

Explore podcasts about the gut-skin-brain axis, the microbiome, and recent clinical advances in acne.

Frequently Asked Questions

What causes acne? +

Acne is a common skin condition that occurs when pilosebaceous units (hair follicles and their associated oil glands) become clogged with excess oil (sebum), dead skin cells, and bacteria. It primarily affects areas of the skin with a high concentration of sebaceous glands, such as the face, back, chest, and shoulders.

Acne is caused by a combination of factors, including:

Excess Oil Production: Sebaceous glands in the skin produce an excess of oil (sebum), which can clog pores.

Clogged Pilosebaceous units: Dead skin cells can accumulate and block hair follicles and their associated oils glands, leading to acne.

Bacteria: The presence of Cutibacterium acnes (C. acnes), which can thrive in clogged pores, may trigger inflammation and infection.

Hormonal Changes: Fluctuations in hormones, particularly during puberty, menstrual cycles, pregnancy, or with the use of hormonal medications, can increase sebum production and lead to acne.

Inflammation: The body’s inflammatory response to bacteria and clogged pores can exacerbate acne, resulting in redness and swelling.

Stress: Stress can lead to increased hormone production, inflammation, and changes in the gut microbiome, which may worsen acne.

Genetics: A family history of acne may increase susceptibility, indicating a genetic component to the condition.

Medications: Certain medications, such as corticosteroids, can provoke or worsen acne.

How do gut health problems relate to acne? +

Here are several ways in which gut problems may contribute to formation:

Gut Microbiome: The balance of bacteria in the gut can influence inflammation and immune responses in the body. An imbalance in gut bacteria may lead to increased inflammation, which can exacerbate acne.

Inflammation: Conditions such as leaky gut syndrome can result in systemic inflammation, which may contribute to acne development. Inflammatory markers in the body can trigger or worsen acne lesions.

Diet: A diet high in refined sugars, dairy, and unhealthy fats can negatively affect gut health and trigger acne breakouts. A healthy gut often correlates with a balanced diet rich in fiber, probiotics, and nutrients.

Hormonal Response: Gut health can influence hormone levels in the body. For instance, an imbalance in gut bacteria may affect hormones that regulate skin oil (sebum) production and skin health, potentially leading to acne flare-ups.

Stress and Skin Conditions: Gut issues can contribute to stress and anxiety, which may also aggravate skin conditions like acne. Managing stress and its physical effects on the body through diet, gut health support, and mindfulness practices may help in supporting skin health.

Can I reduce breakouts with an inside & out solution? +

Yes, addressing gut and skin health together with hormonal balance can potentially reduce acne breakouts:

Gut Treatments: Improving gut health through prebiotics, probiotics and diet can enhance the gut microbiome, which plays a role in immune regulation and inflammation. This may help in reducing the likelihood of breakouts.
Skin Treatments: Balancing skin oiliness and improving skin turnover (desquamation) without harsh topicals while maintaining skin barrier integrity through regular moisturizing can reduce acne breakouts and pore inflammation.

Hormonal Treatments: Balancing sex hormones (especially in cases of PCOS) and reducing stress hormones (cortisol) is important in reducing or even preventing monthly hormonal acne breakouts.
Holistic Approach: Combining these treatments is essential, as they can influence one another. Healthy skin and gut microbiomes can support overall immune function, and balanced hormone levels potentially lower the risk of acne breakouts and their severity.
Consultation with Healthcare Providers: Working with dermatologists, gastroenterologists,AND endocrinologists can help create a tailored management plan that incorporates both gut, skin, and hormone treatments effectively.

How soon can I see results? +

Many customers notice some improvement in about 4 weeks, but for most customers, real improvements can take 8 to 12 weeks.  Patience and consistency are key!